NCP Detected Two New Technologies Or Moved Two Weeks Ago To The "Sentinel Crowd".

"The pro King team is trying to buy next week's air ticket to China to make antibody chip technology and multiple PCR detection technology validation. Our team is already preparing the sample size. If the progress is successful, clinical verification will be able to come out to verify the effect in about a week. This will help solve the problems of false negative and false positive in nucleic acid detection. In February 11th, Lu Jiahai, Professor of Zhongshan University School of public health and director of One Health Research Center, introduced to the twenty-first Century economic report reporter.

Li Pu Jin is known as the "virus Hunter" in the field of international epidemiology. As the first scientist to diagnose pathogens in the world, he trained many medical workers in China during the period of atypical pneumonia. Lu Jiahai pointed out that if the above two technologies are successfully applied, they will play a significant role in the prevention and control of NCP.

Wang Sheng, a famous epidemiologist who has been through the epidemic prevention and control of cholera, plague, smallpox and so on, has rushed to the twenty-first Century economic report reporter, according to the analysis of the epidemic law. Now the rising trend of NCP has been curbed initially, and is now in a platform stage. Professor Wang Sheng, a famous epidemiologist of the epidemic prevention and control of cholera, plague, smallpox, etc. In view of the fact that a large number of light patients and recessive infected persons are scattered around the country and are two factors of reworking period and large population flow, the next two weeks will be the critical moment to fight the new crown virus.

At the same time, Lu Hai Hai stressed that learning from SARS and the NCP lessons, we should better establish a joint defense joint control mechanism and move the gateway forward. "It has been proved that 78% of human infectious diseases are related to wild animals. Therefore, the" One Health "mechanism must be adopted to prevent the virus from moving to the" sentinel crowd "animal workers, including the animals who sell animals, animals, animals, veterinarians, farmers and herdsmen. At the same time, we should expand the interdisciplinary collaboration and communication between the three party health of human, animal and environment. There should be more exchanges and cooperation between public health professionals, doctors and veterinarians.

Two new technology or verification within two weeks

In 2003, at the height of the SARS epidemic in China, Professor Li Pu Jin was invited to Beijing by relevant Chinese authorities to help assess the epidemic situation and formulate a response plan. After the epidemic was brought under control, he helped China set up a series of infrastructures for dealing with infectious diseases.

After the outbreak of a new coronavirus pneumonia, Professor Li Jin Jin has been closely monitoring the development of the epidemic.

In January 30th, Professor Li Pu Jin shared the experience accumulated in the past new infectious disease outbreak in the world at Zhongshan University, introduced the technology of discovery and rapid diagnosis of pathogenic microorganisms, and pointed out that global scientists, especially the United States, should establish close ties with Chinese scientists to develop vaccines, drugs and diagnostic reagents to adjust the treatment plan, and reduce the infection rate and mortality rate of new viruses in China.

Lu Jiahai told the twenty-first Century economic news reporter that Professor Li Pu Jin returned to the United States in February 4th. "Before returning to the United States, he had arranged for his team to work with our team to solve problems together, including how to improve the sensitivity of the kit detection and how to identify the virus."

At present, the screening of fever patients is a new type of coronavirus after fever. The rapid screening kit is being developed urgently. The team members of the pro gold team were scheduled for next week's scheduled flights next week because of problems such as air tickets and flights. If the validation is successful, they will be able to find a way to quickly apply to the current patient screening process.

According to the introduction, the above kit detection is the use of multiplex fluorescence quantitative PCR method, not only can solve the problem of false negative false positive, but also can solve what specific virus problem.

It is also known that Professor Li Pu Jin's team is still studying an antibody chip technology, which can detect not only the new crown virus but also the various pathogens.

"Antibody chip technology requires little sample size, requiring 60 to 100, and multiplex fluorescence quantitative PCR requires about 100 samples. These samples require different stages of disease, including false Yin and false Yang. Earlier, Professor Li Pu Jin said that if the above methods were verified successfully, they would be paid to the Chinese government without compensation. Lu Jiahai told reporters on twenty-first Century economic report.

The next 2-4 weeks will be a critical period for epidemic prevention.

If the above technology is verified successfully, it will play a great role in promoting the prevention and control of NCP epidemic in China in two weeks. Judging from the two factors of the large number of light patients and recessive infected people scattered around the country and the large number of population returning to work, the next two weeks will also be a critical moment for a decisive battle with the new crown virus.

Wang rushed to the twenty-first Century economic report reporter, according to his many years of research on epidemic diseases, determine whether the disease can be popular depends on three factors, namely, virus toxicity, epidemic law, government measures.

The new crown virus has two characteristics: attack power (transmission force / infectivity) is relatively strong. According to the results of the 2019 new coronavirus transmission kinetics (2019-nCoV) study by Guangdong Provincial Center for Disease Control and Prevention (CDC), the new coronavirus R value is 2.90 and 2.92, higher than that of SARS 1.77 and 1.85 (preliminary results need to be verified). The R value refers to the average number of infectious persons that can be transmitted to a few people. R is greater than 1. In the initial stage, the infectious disease becomes an epidemic disease exponentially, and the R value is close to 3, indicating that the new crown virus is more infectious.

On the other hand, the pathogenicity (virulence / death) of the new crown virus is relatively low. The mortality rate is 2.26% (909/40235-2020.2.10.) from the current data, of which Hubei is 2.94% (871/29631), and outside Hubei is 0.36% (38/10604).

According to epidemiological characteristics, there are many light patients and more recessive infections. In Wuhan, some experts believe that the positive rate of nucleic acid in swabs and nasal swabs is only 30%-40%; latent period, light patients and recessive infections are all infectious, and there is no infection in recovery period (for the sake of prudence, it still needs isolation for 7-14 days after recovery). Wang Shengyong said.

Wang Sheng flocked to the twenty-first Century economic news reporter, pointing out that from the current data analysis, the toxicity of the new crown virus has not increased or weakened, and the immune barrier of the population is gradually forming. The most important factor is social factors, that is, powerful prevention and control measures have been effective and gradually effective.

The results of the prediction by Professor Ma Wenjun of the Guangdong public health research institute show that the fast rising trend of the epidemic has been effectively curbed and will soon be on the downward trend of the high platform.

"In view of the fact that a large number of light patients and hidden infections are scattered throughout the country and are the two factors of reworking large numbers of people, the next two weeks will be the critical moment for our battle against the new crown virus, so we must not be careless and relaxed. If we stick to the current 2-4 weeks' prevention and control measures, we will be better able to win the battle.

Wang said that the current decision on containment tactics, the introduction of external defense and the prevention of internal proliferation are correct, including the fire god Hill Hospital, Raytheon Hill Hospital and shelter hospital, but all localities should suit local conditions and not all follow suit. At present, the areas where sporadic distribution is carried out are "isolated sources of infection, effective containment, severing channels, focusing on the community". For light patients and contacts, it is recommended that "home segregation or family separation and community management" be the main means.

The gateway moved to "sentinel crowd"

Lu Jiahai also said that based on the community based prevention and control, at the same time, in the tide of rework, public health input needs to be strengthened.

"We hope that the CDC and public health people can sink to the community, guide, assess and assess the current measures taken by the state to see which effects are useful, the most simple and the most acceptable, so that we can reduce the rate of disease infection at the front-end of disease prevention and control, so that we can effectively reduce the burden and pressure of medical workers."

In this China trip, Li Pu Jin also proposed how to deal with the new coronavirus. One of the ways to prevent such incidents from repeating itself is to restrict the market of wildlife trafficking, which is the source of many similar viruses.

On the evening of February 9th, Chen Huanchun, a member of the Chinese Academy of engineering and a professor of Huazhong Agricultural University public health research group and professor of Huazhong Agricultural University, said that the 78% emerging infectious diseases are related to wild animals or wild animals.

Lu Jiahai told the twenty-first Century economic news reporter that such a disease transmitted from animals to humans is called "zoonosis."

It is understood that the coronavirus in the human body was first isolated in Britain in 1960s. The virus is named for its crown like prominence. It may be associated with respiratory infection in humans, pigs, cats, dogs, rats and chickens. The SARS virus appeared in China in 2003 and the MERS virus discovered in Saudi Arabia in 2012 were all coronaviruses.

"From the lessons of many epidemics, to change the passive situation of epidemic prevention, we must move ahead with the epidemic prevention. The object of this move is animal workers, including those who sell animals, animals, animals, veterinarians, farmers and herdsmen, who are high-risk groups. If we take the initiative to strengthen their testing, we will be able to detect them early. They are sentinel groups." Lu Jiahai said.

Lu Jiahai pointed out that purely public health departments (or disease prevention departments) can not fundamentally solve problems. Animal borne infectious diseases must be jointly studied by the agricultural sector, veterinary departments and wildlife departments. At present, the relationship between people and the environment is becoming more and more close. It requires people to carry out multi-disciplinary, cross regional, cross sectoral and cross national cooperation to face complex human health problems or health problems. This is One Health.

(interns Liu Zhixi and Liu Mengyu contributed to this article)