Antibody Detection Is An Important Part Of Anti Epidemic Rehabilitation. Antibody Quality Is More Important Than Detection Results.

Antibody detection is becoming one of the most important actions against the new crown pneumonia epidemic.

In April 22nd, the Central Committee meeting of the leading group of the new crown pneumonia epidemic work pointed out that there were some local epidemic cases, and there were cross infection in some places. We should take the warning as a warning and attach great importance to the prevention of clustered epidemics, especially nosocomial infections. We should speed up the detection capability and carry out large-scale nucleic acid and antibody tests. The key groups should be checked and checked; all localities should strengthen epidemic prevention and control during the May 1 holiday, and strengthen and perfect the epidemic prevention and control work at border ports.

China's CDC has also launched a nationwide survey of new crown virus serological epidemiology, including Beijing, Liaoning, Shanghai, Jiangsu, Zhejiang, Hubei, Guangdong, Sichuan, Chongqing and other 9 provinces and municipalities nationwide and Wuhan city. The purpose is to determine whether antibodies have been produced in the population to assess the size and immune level of asymptomatic infections in the population. Among them, the epidemiological survey of serum samples of residents in Wuhan was launched in April 14th, with a total number of 11 thousand.

Worldwide, those who produce antibodies will be the first to return to normal production and life. In the eyes of many experts, identification of people who have been immunized by antibody detection will provide a basis for further implementation of fine isolation and prevention of scientific control measures such as Feng Cheng. People who have already produced antibodies, especially medical workers, can resume their daily work first.

Global antibody detection is hot.

The fight against the epidemic was completely carried out with antibody detection and nucleic acid detection.

Ali health data show that since the online booking service on the line, the consultation volume of nucleic acid detection has increased sharply, reflecting the urgency of the demand of all sectors of society in the context of resumption of production. Among them, Shanghai, Guangzhou, Hangzhou, Wuhan, Ji'nan, Harbin and so on are the most frequently consulted, and these cities are the forerunners of promoting the resumption of work and rehabilitation. Taking Shanghai as an example, the city's health and Health Committee said recently that in order to support enterprises, institutions and schools to resume work and resume production and meet the needs of society, Shanghai units or individuals could make an appointment to carry out the new crown virus nucleic acid detection according to the principle of voluntary self payment.

The new crown virus antibody was detected by colloidal gold technique. Many bio pharmaceutical companies such as the 100 American company and Becton Dickinson company have developed the new crown antibody detection kit, which can detect IgM/IgG antibodies quickly. Many enterprises in China also have a 15 minute rapid detection technology for new crown antibodies.

However, due to the fact that nucleic acid detection is currently used as the "gold standard" for the detection of new crown virus in China, and the cost of antibody detection is much lower than that of nucleic acid detection, many enterprises in China are unwilling to produce rapid antibody detection kits for profit reasons, and prefer to produce nucleic acid detection kits. Many industry insiders told the twenty-first Century business reporter that antibody testing kits are now busy with export.

According to an immunology expert from a university in Beijing, the new crown antibody test kit he bought for research needs only 35 yuan RMB, and nucleic acid detection is at least 10 times more than that of antibody detection.

The reporter has inquired from the website of the medical device product registration website of the State Administration of drug control. At present, a total of 25 enterprises in China have been approved to produce the new crown virus detection kit. Among them, 8 companies like Guangzhou Wanfu biology and Nanjing nuwei Zan are registered to produce antibody detection kits, others are nucleic acid detection reagent manufacturers.

    Wang Chen, the convener of the comprehensive expert group of the Chinese Academy of engineering and the Hubei provincial Ministry of prevention and control, said that the epidemiological investigation of nucleic acid and serum antibodies is the most critical scientific evidence to grasp the epidemic pattern of new crowns. To do a good job in the epidemiological investigation of nucleic acid and serum antibodies is a crucial task for the future scientific control and prevention. The direct effect of birth.

Most experts suggest that antibody tests should be conducted first in Wuhan and Hubei.

Professor Jiang Qing, former president of Fudan University School of public health and member of the new prevention and control expert group of the Chinese Preventive Medicine Association, said that it is necessary for epidemiologic investigators to conduct epidemiological sampling of antibodies in Wuhan. It is an important way to confirm the data of recessive infection. It is related to whether the new crown pneumonia will come back and how to deal with it after a comeback. He believes that the investigation can be partly aimed at the high exposure population of the close contacts such as the previously excluded cases, and partly for the general population. According to the total number of confirmed patients in Wuhan, at least 2500 people or more should be sampled to reflect the overall situation.

Around the world, many public health experts and policymakers have also bested the hope of the new outbreak in the body's own immunity. Before the vaccine can not be "expected" in the short term, antibody detection is also indispensable.

In April 9th, Germany launched the first large-scale antibody testing project in Europe, one of the most popular areas in Germany, Hines Begg, with a sample of 1000 people.

Hou Jinlin, director of the Department of internal medicine of Nanfang Hospital, Southern Medical University, told the twenty-first Century economic report that more antibodies were used in screening abroad. Because antibodies were relatively early, they produced IgM and then produced IgG. The patients diagnosed with nucleic acids had these two antibodies, including asymptomatic infections.

Testing quality is the key.

The IgM kit is characterized by blood test and rapid results, but the biggest problem is accuracy. Antibody production takes time, and there is a certain time window for detection. In principle, when the virus invades the body and the body feels the external stimuli, it will produce protective proteins, which is what we call everyday.

The principle of the new coronavirus IgM/IgG detection kit is to detect antibodies by antigen and detect the presence of corresponding antibodies in the human body.

The false positive detection of antibodies, which means poor specificity, is particularly worth vigilance, because it will make those who actually do not have antibodies mistakenly believe that they have immunity, and free access in social life.

"False positive detection of antibody testing is a common problem. For the new crown, how serious the problem will be is not known, because there is a lack of data." Zhang Hongtao, an associate professor at University of Pennsylvania School of medicine, said that coronavirus, such as the gastrointestinal tract, is very common and its symptoms are not obvious. Therefore, people who are positive can not tell whether they are cross positive due to these coronaviruses.

In the United Kingdom, the government ordered 3 million 500 thousand test reagents from several companies in late March, but found that none of these reagents were satisfactory. John Bell, a professor of Royal medicine at University of Oxford, pointed out that they have been testing the accuracy of commercial antibody test reagents, and none of them has reached the standard of verification. Many false negative and false positive problems have been found in John Bell.

      However, it is still widely accepted that antibody detection is an important part of the process: on the one hand, it can help public health experts to find out exactly what is happening in the crowd, especially the number of mild and asymptomatic infections. On the other hand, it can know the proportion of antibody in the middle class, and help the future vaccine to answer "what kind of vaccine should be given to people?" "What is the approximate range of vaccination?"